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Mylan launches FDC drug for HIV

Mylan Pharmaceuticals has launched a fixed dose combination drug in India for treatment-experienced adults and adolescents weighing more than 40 kg with HIV-1.

The product, DURART R 450, comprises Darunavir/Ritonavir 400/50mg. Alternative treatments require patients to take two drugs separately. This is the first FDC drug available to patients in India, the company said in a release on Thursday.

President (India and Emerging Markets) Rakesh Bamzai said patients with HIV-1 will now have access to the fixed-dose combination therapy which may improve the overall patient treatment outcomes. Darunavir and Ritonavir are HIV protease inhibitors and can be used in combination for patients failing first and second-line regimens during the management of HIV-1 infection. Darunavir is currently available in India in 600 mg and 800 mg dose forms and Ritonavir is available in the 100 mg and 50 mg dose forms.

The company’s ARV portfolio includes 14 APIs and 50 finished dosage forms in first-line, second-line and paediatric formulations, the release said.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Hyderabad / by Special Correspondent / Hyderabad – November 16th, 2017

Pattiseema Project sets another record

Hyderabad :

Pattiseema project has added another feather to its hat. Megha Engineering & Infrastructures Ltd. (MEIL), which set a record in the execution of the Pattiseema project, has set another record by diverting 100 TMC of water from River Godavari to River Krishna through a lift system in 148 days.

Pattiseema project is a prestigious project of the AP government that has linked both Krishna and Godavari. The project was taken up to divert 80 TMC of water from Godavari and Krishna in 110 days. In this year, the project has diverted 100 TMC of water in 148 days. This is an increase of 20% over the intended usage of the project.

Official sources said Pattiseema is the only project in India to divert 100 TMC of water in one season. In this year, 98% of the acreage under river Krishna has been brought under cultivation.

“Normally, in any lift irrigation project, the pumps and motors are put to use only for three months or less every year. In Pattiseema project, all the 24 motors have been functional for the last 4 months. The 24 motors, one lakh twenty thousand hours, 159 TMC of diverted water,” a senior official of AP Irrigation department said.

Interestingly, the project was completed before time by the project contractor MEIL and subsequently entered into the Limca Book of Records for diverting 100 TMC of water this year from River Godavari to Krishna Delta. The works began on March 30, 2015 and completed the works by March 20, 2016.

Officials said Pattiseema is the first project in India to be completed on time without any budgetary enhancements. In spite of many challenges and setbacks, the government planned diligently and employed a workforce of 2,000 to complete the project. The first pump was made functional in 173 days (on 18th September 2015) and water was released.

According to a release, the pump house which is spread across an area of 7476 sq. m. is the largest in Asia. The project pumps 240 cusecs of water through 24 pumps. After the completion of the project, the pumps have been operational for 1.2 lakh hours till now. This means that each pump has been operational for 5000 hours without any hurdles. The pumps were successful in diverting 4 TMC of water in 93 days in the first year (2015), 55.6 TMC of water in 137 days in 2016, and 148 TMC of water till now in 2017.

Irrigation officials said this year, the farmers of Krishna Delta received water to their farmlands in the beginning of July. This has never happened in the past.

These farmers sowed their paddy crops in the months of October and November every year due to water scarcity. They incurred heavy losses when their crops were inundated during the monsoons and other calamities. After the completion of the Pattisam project, the farmers have started receiving water on time. As a result, they are reaping the benefits of a good harvest without any obstacles. The officials from irrigation and water resources department are able to ascertain the actual reason behind such abundant harvests.

source: http://www.timesofindia.indiatimes.com / The Times of India / News> City News> Hyderabad News> Civic News / by Koridi Mahesh / TNN / November 16th, 2017

Hyderabad: 1,000 kgs of waste recycled to make cube-glass stools, rubber planters

After the summit, the street furniture will be shifted to parks or the Necklace Road.

Trash piled up at a collection centre in Hyderabad on Monday. (Photo: DC)

Hyderabad:

A tonne of trash, 85 used rubber tyres and four drums disposed of by residents in the west zone have been used to make street furniture for the Global Entrepreneur’s Summit to be held in Hyderabad from November 28.

Two tetra-pack toilets, a cube glass stool, furniture made from rubber tyres and tiles made of plastic will be displayed near HICC, the venue of the summit, from November 26. The trash was collected from the dry waste centre at Serilingampally. After the summit, the street furniture will be shifted to parks or the Necklace Road.

A sculpture made of multicoloured chips packets, polythene covers, plastic bottles, metal wires and old shoes will be placed at the entrance of HICC. The cube-glass stools, currently displayed on Madhapur street, are made of both metal angles and 8 mm toughened glass filled with scrap such as chips packets and soft drink cans.

Some 85 discarded rubber tyres were made into an all-weather sofa set that can be used both indoors and outdoors. The metal drums have been fashioned into chairs and tables.

Prashanth Lingam of Bamboo India, who has worked on these items in coordination with the Greater Hyderabad Municipal Corporation, said that the scrap was provided free of cost by the GHMC which also paid for the labour.

He said 1,000 kgs of trash was recycled to make the cube-glass stools, rubber planters, rubber based sofa, and tiles made of plastic.

“We are working on a tetra pack toilet and trash man. The idea is to showcase recycling using daily used scrap and put it to functional use in public spaces as a street art form or public utility,” he said.

West Zone Municipal Commissioner Hari Chandana Dasari said, “GHMC is making efforts to promote recycling and reuse waste. The street furniture is all made from waste that people have generated. The wrappers were collected by GHMC teams and the tyres were mostly from heavy duty GHMC vehicles which will be used as planters.”

source: http://www.deccanchronicle.com / Deccan Chronicle / Home> Nation> Current Affairs / by Coreena Suares, Deccan Chronicle / November 14th, 2017

IIT Hyderabad develops novel skin patch for constant drug release

Optimum “The drug gets released quickly when the pore size of the nanofabric is 100 microns,” says Mudrika Khandelwal (second from right).

The amount of drug in the patch can be modified so that it is released at desired rate

Researchers at the Indian Institute of Technology (IIT) Hyderabad have developed a novel drug-delivery system that releases a commonly used pain killer (diclofenac sodium) at the target site in a controlled fashion such that there is constant release of the drug for as long as 12 hours. The drug has low half-life of one–two hours and so constant release for up to 12 hours becomes particularly significant.

In normal circumstances, the drug gets metabolised very quickly, thereby requiring frequent dosing to maintain the desired therapeutic levels. The fluctuation of the drug plasma level is one reason why the medicine cases adverse effects.

To prevent burst or quick release of the drug, a team led by Mudrika Khandelwal from the Department of Materials Science and Metallurgical Engineering at IIT Hyderabad fabricated a transdermal patch containing the drug and made the patch highly hydrophobic (water repelling). The high hydrophobicity of the patch ensures that the highly water-soluble drug is released in a slow and sustained fashion. The results were published in the journal Applied Surface Science.

Tuning the patch

What makes the transdermal patch particularly significant is the freedom to increase the amount of drug present in the patch so that the drug is constantly released at a therapeutically desirable dosage for a longer duration.

The patch was prepared by mixing the drug with cellulose acetate bio-polymer and electrospun in the form of a nanofabric. Ordinary nylon mesh with different pore sizes (50, 100 and 200 microns) was used at the site of the collector and this allowed the nanofibres to get deposited with micron-sized gaps in between.

“The non-wetting capillary action of the air pockets pushes the water away and this changes the water contact angle from about 30 degrees to 138 degrees and makes the nanofabric hydrophobic.

There is higher non- wetting capillary action of the air pockets when the air gaps are smaller in size,” says Prof. Chandra Shekhar Sharma from the Department of Chemical Engineering at IIT Hyderabad and one of the authors of the paper. “Since the drug is released through a diffusion process, the increased water repelling nature (hydrophobicity) of the fabric reduces the effective area in contact resulting in reduced diffusion rate, which also reduces the drug release.”

Constant release

“The drug, which is embedded in the transdermal patch, is released at a constant rate for up to 12 hours, when the pore size of the nanofabric is 50 microns. We achieved constant release for only three hours when the pore size was 100 microns. The drug without any micropatterning was released in just one hour,” says Dr. Khandelwal who is the corresponding author of the paper.

“We tested transdermal release using a membrane that mimics the skin. The membrane separates the drug-loaded nanofabric from a solution that in turn mimics the body fluids,” says Dr. Khandelwal. “Different drugs can be loaded in the nanofibres to achieve constant release for a long time.”

“We embedded ciprofloxacin antibiotic in the patch and achieved similar results. The transdermal patch loaded with the pain killer [diclofenac sodium] can be used for treating local muscular pain. It may not be possible to treat deep-seated pain using this patch,” says Shivakalyani Adepu from the Department of Materials Science and Metallurgical Engineering at IIT Hyderabad and the first author of the paper.

The researchers plan to develop transdermal patch prototypes and test them on animals.

source: http://www.thehindu.com / The Hindu / Home> Sci-Tech> Science / by R. Prasad / November 11th, 2017

On footpath, techie spreads breakfast table for hungry

Hyderabad :

Every Sunday morning, an IT and e-commerce consultant and his wife turn into ‘good Samaritans’ for people waiting on pavements outside Basavatarakam Indo-American Cancer Hospital and Research Centre near KBR Park. Vijay Kumar N, who started a small firm after spending a decade in London, does not miss a single Sunday driving down to the hospital on road number 10 in Banjara Hills for providing breakfast to the needy and poor.

About 150-200 people queue up every Sunday on the pavement outside the hospital between 7am and 7.30am for breakfast

Scores of people queue up on the pavements from 7 to 7.30am for breakfast. Vijay and his wife have been doing this for the past two years. “On a winter morning on Sunday two years ago, I had taken my daughter for a joyride from Jubilee Hills to KBR Park. I was taken aback by the plight of the people waiting outside the hospital.

Some of them were family members of patients undergoing treatment at the hospital. Most of them cannot afford food or accommodation in Banjara Hills. Many beggars also live on the pavement adjacent to the hospital,” Vijay told TOI. He still recalls the face of a young cancer patient groaning in pain on the pavement.

“I was even more shocked to see the young boy, perhaps six or seven years old, lying on the pavement with a tube inserted in his nose. I got down from my car found out that he was suffering from lung cancer. His parents were running from pillar-topost to get him admitted at the hospital.

This sight gave birth to the idea of helping these people,” he said. “My wife gave me the idea to make food and serve it to all the poor people there, including those begging for alms. That day, two years ago, she made upma and both of us went back there and fed around 10 persons,” added Vijay. Now, they feed 150-200 people every Sunday. “Feeding breakfast to the needy makes it a happy Sunday for my family. Just by feeding them breakfast, we cannot bring smiles on their faces, but it is a small effort on our part to do something for them,” Vijay said.

source: http://www.timesofindia.indiatimes.com / The Times of India / News> City News> Hyderabad News / Sarthak G / TNN / November 13th, 2017

RedBus co-founder named Telangana’s Chief Innovation Officer

Hyderaba :

The Telangana Government has appointed Phanindra Sama, who Co-Founded bus ticketing company RedBus and serial entrepreneur, as Chief Innovation Officer of the State.

A South African investment firm had acquired RedBus for about Rs. 780 crore. After the successful exit, Phanindra Sama has been working with start-ups and overseeing the activities of Kakatiya Sandbox in Nizamabad.

Phanindra received the formal appointment letter from Telangana IT and Industries Minister KT Rama Rao at Secretariat on Friday.

Phanindra will head the State’s Innovation Cell, which aims at promoting innovation at the grass root level, catching the school children in rural areas very young.

“The Cell will also focus on bringing the startup ecosystem closer by promoting a State-as-a-whole approach as opposed to concentrating startup activity in one location. It proposes to develop co-working spaces and incubators across the State,” a Government official said later.

source: http://www.thehindubusinessline.com / Business Line / Home> News> National / by KV Karmanath / Hyderabad – November 11th, 2017

Outlining the journey of city police

Chief Minister K. Chandrasekhar Rao, freelance writer Noopur Kumar, outgoing DGP Anurag Sharma and his successor M. Mahender Reddy releasing the book on Saturday.

Chief Minister K. Chandrasekhar Rao releases a book on city police

A coffee table book Journey of the Hyderabad City Police written by freelance writer Noopur Kumar was released by Chief Minister K. Chandrasekhar Rao here on Saturday. The book is a compilation of the progress of city police since the inception till date and is embellished with oil paintings.

The journey has been explained in a racy style right from the days when the police patrolled the city thoroughfares on bicycles to the installation of CCTV cameras.

The book deals with the speciality of Hyderabad on law and order front, the Kotwal regime of policing during Qutub Shahi rule, the police network during the subsequent Nizam’s period, the great Ganga Jamuna Tehzeeb of Hyderabad where Hindu and Muslims lived in harmony and the great personalities in the Police Department.

Mr. Rao congratulated Ms. Kumar for bringing out the book. Additional DGP Anjani Kumar supervised its production. The outgoing DGP Anurag Sharma, his successor M. Mahender Reddy and Chief Advisor to Government Rajiv Sharma participated.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Hyderabad / by Special Correspondent / Hyderabad – November 11th, 2017

University of Hyderabad research scholar presents paper at US conference

ICOTOM is a global scientific exchange focusing on real-world scientific solutions

UoH research scholar Sabavath Janakiram. Photo from university newsletter

Hyderabad:

A research scholar from University of Hyderabad presented a paper on ‘texture evolution during partial recrystallisation annealing in high strength automotive steels’, at a global conference held in the US, a newsletter published by the university said.

Sabavath Janakiram is pursuing his PhD in Materials Engineering in the School of Engineering Science and Technology, UoH. He was invited to participate in the International Conference on Textures of Materials (ICOTOM-18), which was held from November 5 to November 10, at St George, Utah.

ICOTOM is a global scientific exchange focusing on real-world scientific solutions.

Janakiram specialises in ‘nucleation texture and microstructure control during early recrystallisation annealing of high strength automotive steels’ under the supervision of Dr Jai Prakash Gautam at the university, the newsletter said.

His visit was funded by Prof Leo Kestens from University of Ghent and the National Science Foundation.

Janakiram’s research paper will be published in the Journal of Physics: Conference Series Materials Science and Engineering.

source: http://www.telanganatoday.com / Telangana Today / Home> Hyderabad / November 10th, 2017