Mylan Pharmaceuticals has launched a fixed dose combination drug in India for treatment-experienced adults and adolescents weighing more than 40 kg with HIV-1.
The product, DURART R 450, comprises Darunavir/Ritonavir 400/50mg. Alternative treatments require patients to take two drugs separately. This is the first FDC drug available to patients in India, the company said in a release on Thursday.
President (India and Emerging Markets) Rakesh Bamzai said patients with HIV-1 will now have access to the fixed-dose combination therapy which may improve the overall patient treatment outcomes. Darunavir and Ritonavir are HIV protease inhibitors and can be used in combination for patients failing first and second-line regimens during the management of HIV-1 infection. Darunavir is currently available in India in 600 mg and 800 mg dose forms and Ritonavir is available in the 100 mg and 50 mg dose forms.
The company’s ARV portfolio includes 14 APIs and 50 finished dosage forms in first-line, second-line and paediatric formulations, the release said.
source: http://www.thehindu.com / The Hindu / Home> News> Cities> Hyderabad / by Special Correspondent / Hyderabad – November 16th, 2017
After the summit, the street furniture will be shifted to parks or the Necklace Road.
A tonne of trash, 85 used rubber tyres and four drums disposed of by residents in the west zone have been used to make street furniture for the Global Entrepreneur’s Summit to be held in Hyderabad from November 28.
Two tetra-pack toilets, a cube glass stool, furniture made from rubber tyres and tiles made of plastic will be displayed near HICC, the venue of the summit, from November 26. The trash was collected from the dry waste centre at Serilingampally. After the summit, the street furniture will be shifted to parks or the Necklace Road.
A sculpture made of multicoloured chips packets, polythene covers, plastic bottles, metal wires and old shoes will be placed at the entrance of HICC. The cube-glass stools, currently displayed on Madhapur street, are made of both metal angles and 8 mm toughened glass filled with scrap such as chips packets and soft drink cans.
Some 85 discarded rubber tyres were made into an all-weather sofa set that can be used both indoors and outdoors. The metal drums have been fashioned into chairs and tables.
Prashanth Lingam of Bamboo India, who has worked on these items in coordination with the Greater Hyderabad Municipal Corporation, said that the scrap was provided free of cost by the GHMC which also paid for the labour.
He said 1,000 kgs of trash was recycled to make the cube-glass stools, rubber planters, rubber based sofa, and tiles made of plastic.
“We are working on a tetra pack toilet and trash man. The idea is to showcase recycling using daily used scrap and put it to functional use in public spaces as a street art form or public utility,” he said.
West Zone Municipal Commissioner Hari Chandana Dasari said, “GHMC is making efforts to promote recycling and reuse waste. The street furniture is all made from waste that people have generated. The wrappers were collected by GHMC teams and the tyres were mostly from heavy duty GHMC vehicles which will be used as planters.”
source: http://www.deccanchronicle.com / Deccan Chronicle / Home> Nation> Current Affairs / by Coreena Suares, Deccan Chronicle / November 14th, 2017
The amount of drug in the patch can be modified so that it is released at desired rate
Researchers at the Indian Institute of Technology (IIT) Hyderabad have developed a novel drug-delivery system that releases a commonly used pain killer (diclofenac sodium) at the target site in a controlled fashion such that there is constant release of the drug for as long as 12 hours. The drug has low half-life of one–two hours and so constant release for up to 12 hours becomes particularly significant.
In normal circumstances, the drug gets metabolised very quickly, thereby requiring frequent dosing to maintain the desired therapeutic levels. The fluctuation of the drug plasma level is one reason why the medicine cases adverse effects.
To prevent burst or quick release of the drug, a team led by Mudrika Khandelwal from the Department of Materials Science and Metallurgical Engineering at IIT Hyderabad fabricated a transdermal patch containing the drug and made the patch highly hydrophobic (water repelling). The high hydrophobicity of the patch ensures that the highly water-soluble drug is released in a slow and sustained fashion. The results were published in the journal Applied Surface Science.
Tuning the patch
What makes the transdermal patch particularly significant is the freedom to increase the amount of drug present in the patch so that the drug is constantly released at a therapeutically desirable dosage for a longer duration.
The patch was prepared by mixing the drug with cellulose acetate bio-polymer and electrospun in the form of a nanofabric. Ordinary nylon mesh with different pore sizes (50, 100 and 200 microns) was used at the site of the collector and this allowed the nanofibres to get deposited with micron-sized gaps in between.
“The non-wetting capillary action of the air pockets pushes the water away and this changes the water contact angle from about 30 degrees to 138 degrees and makes the nanofabric hydrophobic.
There is higher non- wetting capillary action of the air pockets when the air gaps are smaller in size,” says Prof. Chandra Shekhar Sharma from the Department of Chemical Engineering at IIT Hyderabad and one of the authors of the paper. “Since the drug is released through a diffusion process, the increased water repelling nature (hydrophobicity) of the fabric reduces the effective area in contact resulting in reduced diffusion rate, which also reduces the drug release.”
“The drug, which is embedded in the transdermal patch, is released at a constant rate for up to 12 hours, when the pore size of the nanofabric is 50 microns. We achieved constant release for only three hours when the pore size was 100 microns. The drug without any micropatterning was released in just one hour,” says Dr. Khandelwal who is the corresponding author of the paper.
“We tested transdermal release using a membrane that mimics the skin. The membrane separates the drug-loaded nanofabric from a solution that in turn mimics the body fluids,” says Dr. Khandelwal. “Different drugs can be loaded in the nanofibres to achieve constant release for a long time.”
“We embedded ciprofloxacin antibiotic in the patch and achieved similar results. The transdermal patch loaded with the pain killer [diclofenac sodium] can be used for treating local muscular pain. It may not be possible to treat deep-seated pain using this patch,” says Shivakalyani Adepu from the Department of Materials Science and Metallurgical Engineering at IIT Hyderabad and the first author of the paper.
The researchers plan to develop transdermal patch prototypes and test them on animals.
source: http://www.thehindu.com / The Hindu / Home> Sci-Tech> Science / by R. Prasad / November 11th, 2017
ICOTOM is a global scientific exchange focusing on real-world scientific solutions
A research scholar from University of Hyderabad presented a paper on ‘texture evolution during partial recrystallisation annealing in high strength automotive steels’, at a global conference held in the US, a newsletter published by the university said.
Sabavath Janakiram is pursuing his PhD in Materials Engineering in the School of Engineering Science and Technology, UoH. He was invited to participate in the International Conference on Textures of Materials (ICOTOM-18), which was held from November 5 to November 10, at St George, Utah.
ICOTOM is a global scientific exchange focusing on real-world scientific solutions.
Janakiram specialises in ‘nucleation texture and microstructure control during early recrystallisation annealing of high strength automotive steels’ under the supervision of Dr Jai Prakash Gautam at the university, the newsletter said.
His visit was funded by Prof Leo Kestens from University of Ghent and the National Science Foundation.
Janakiram’s research paper will be published in the Journal of Physics: Conference Series Materials Science and Engineering.
IT firm Cyient has bagged the CII Industrial Innovation Award 2017.
The award recognises the company as one of the ‘Top 26 Innovative Organisations’ in the country, a release from Cyient said.
Instituted by CII in 2014, the award recognises and celebrates innovative Indian enterprises and budding start-ups across industry segments on an annual basis. For the 4th edition of the awards, the grand jury, comprising leaders in technology, business and the innovation space, evaluated the applications and declared the winners.
The winning organisations were honoured at an awards ceremony held during the CII Industrial Innovation Summit 2017. Cyient was felicitated by Naushad Forbes, past chairman of CII. According to the release, CII praised Cyient for its initiatives, especially the Eye Anatomy Visualization through AR/VR for L V Prasad Eye Institute. The project helped enhance medical learning through visualization and experiential interaction related to the anatomy of the eye by using emerging Augmented Reality/Virtual Reality technologies.
Another initiative of the company was Precision Agriculture Technologies, a project involving use of Unmanned Aerial Vehicles (UAV/drones) to optimise consumption of fertilisers and pesticides in farming.
source: http://www.thehindu.com / The Hindu / Home> News> Cities> Hyderabad / by Special Correspondent / Hyderabad – November 07th, 2017
Microsoft CEO will also deliver the keynote address at the first edition of the India Today Conclave Next 2017.
Microsoft CEO Satya Nadella is on a two-day visit to India to promote his book Hit Refresh – The Quest to Rediscover Microsoft’s Soul and Imagine a Better Future for Everyone.
The tech giant’s India-born chief will be in Delhi on November 7 to deliver the keynote address at the first edition of the India Today Conclave Next 2017. Nadella kickstarted his trip with a visit to Microsoft’s headquarters in Hyderabad on November 6 – the city of his birth – where he joined NDTV’s Prannoy Roy for a discussion on his book that will soon be available in Hindi, Telugu, and Tamil.
The book takes readers through Nadella’s personal journey from his childhood in India to his ascendancy through the ranks at Microsoft. It talks about the transformation he has initiated at Microsoft, from its culture to its competitive landscape and industry partnerships as well as his outlook on the exciting and disruptive wave of technologies that will impact all our lives in the coming days.
Many of these themes will also be explored at the day-long India Today Conclave Next 2017.
Nadella’s book also carries a foreword by Microsoft co-founder Bill Gates. The book’s English edition, launched on September 26, 2017, can already be found in bookstores, while the Hindi edition, published by HarperCollins India will be available in bookstores by November end.
The Tamil and Telugu editions published by Westland Books will be available in print at bookstores from November 7. A Kindle version of the Tamil edition will also be available for download on the same day.
source: http://www.dailyo.in / Daily O / Home> Sci-Tech / November 06th, 2017
Digital Domain, a leading player in the visual effects arena, has made a foray into India with the opening of a studio in Hyderabad.
This is the fifth studio and the tenth location globally for the company, which earlier this year opened facilities in Beijing and Hong Kong. The company, whose visual effects appear in films such as Titanic, The Curious Case of Benjamin Button and Spider-Man: Homecoming and Beauty and the Beast, is keen on shaping the 42,000 sq.ft. facility in Hyderabad into the role of a mainstay for it.
Pegging the investment on the new facility in the $3-5 million range, chief operating officer Amit Chopra, in an interaction with the media on Monday, said: “India is and will continue to be an integral part of Digital Domain’s global expansion plans.”
“We foresee the region to be a leading consumer of premium content,” he said, even as Sudhir Reddy, head of Digital Studio, India, chipped in saying the company was keen on taking up work for customers in the country as well. To begin with, the Hyderabad studio would rely on international projects — movies, commercials as well as VR/AR work — before the demand for its services, especially from Bollywood, is expected to pick up.
“Combined with the recent projections for smart phone growth and mobile bandwidth expansion in the region, the people of India are primed to demand and expect premium content, and we are ready to deliver on that need,” Global CEO Daniel Seah said in a statement.
Of the 500 people who can be accommodated at the new facility, 205 are already on board. By mid-2018, the headcount would touch 500, added Mr. Reddy. Globally, Digital Domain employed 1,400 people.
The new studio, inaugurated on Sunday by Telangana IT Minister K.T. Rama Rao, is at present involved with four big projects, the details of which the senior executivesrefused to share.
source: http://www.thehindu.com / The Hindu / Home> Business / by Special Correspondent / Hyderabad – November 06th, 2017
Vama Industries Ltd., a Hyderabad-based IT infrastructure and ITeS company, has bagged a ₹35.42-crore order for Hierarchical Storage Management System from the Indian Space Research Organisation (ISRO).
The order is towards the supply, installation, integration and testing commissioning of computer infrastructure, Hierarchical Storage Management System as well as network elements for data processing and exploitation system, the company said on Wednesday.
Describing the order from the ISRO as very significant for the company, chairman and managing director V.A. Rama Raju said that Vama Industries was keen on expanding business across different locations across the country.
source: http://www.thehindu.com / The Hindu / Home> News> Cities> Hyderabad / by Special Correpondent / Hyderabad – November 02nd, 2017
An 81-year-old man became the recipient of the world’s smallest pacemaker in city on Tuesday .
The leadless pacemaker, which has been approved by the U.S. Food and Drug Administration (FDA) only a year back, is a new heart device that offers the most advanced pacing technology at onetenth the size of a traditional pacemaker, said D. Bharat V Purohit, chief of Interventional Cardiology , Continental Hospitals, Hyderabad, where the procedure was carried out.
Pacemakers are the most common way to treat Bradycardia to help restore the heart’s normal rhythm.
“The gentleman had slow heartbeat and was suggested a pacemaker. In view of prior history of angioplasty for which he is on blood thinner, stopping the medicines for doing conventional pacemaker would have caused a risk.Besides in view of advanced age, he was very reluctant for any surgical procedure. Hence option of this leadless pacemaker was discussed and decided,” said Dr Bharat V Purohit.
The pacemaker was implanted through the leg. It was attached directly to the walls of the heart to give electrical signals for maintaining a normal heart rate.
source: http://www.timesofindia.indiatimes.com / The Times of India / News> City News> Hyderabad News / TNN / November 01st, 2017
The International Institute of Information Technology, Hyderabad (IIIT-H) is working on components of driverless car technologies.
“We are actually working on components of driverless car. We are not hoping that the car will be running on Hyderabad roads without a driver,” IIIT-H director P J Narayanan told reporters.
But it is a problem that practically every good group in the world is working. It poses several academic challenges,” he said.
Though the goal is a driverless car, the research into the subject would help understand many other things, he said.
“Driverless car, that’s our goal. It’s not easy to have a driverless car on Indian roads… But, the purpose is you develop technologies for it, you learn a lot for other things.
“Instead of driverless car, how can you make our car safer. How can you help our drivers with automatic help…,” he said.
The institute is working on a project for providing data on the condition of roads in Hyderabad to the government agencies, Narayanan said.
Under the project, a car fitted with cameras is proposed to be sent on the roads and the cameras would capture images on the condition of roads.
“…Just send a car with a video. Not driverless. Somebody driving it. And the car will record the video and at the back end information algorithms will detect where are the problem points. This information will help GHMC (Hyderabad civic body) or government to collect,” he said.
The institute runs a car with the technology within its campus under controlled conditions as part of its research, he said.
source: http://www.economictimes.indiatimes.com / The Economic Times / ET Home> Industry> Auto> News> Industry / PTI / October 24th, 2017