Monthly Archives: August 2019

Now, an oral drug to treat deadly kala-azar — IIT Hyderabad says it’s faster, better

Researchers at IIT Hyderabad say the pills will ensure controlled release of the drug used to treat the disease, bettering a patient’s chance of survival.

New Delhi: 

Researchers at the premier Indian Institute of Technology, Hyderabad, have formulated oral tablets that they say will ensure better and faster treatment of the deadly parasitic disease visceral leishmaniasis, commonly known as kala-azar or black fever.

Kala-azar is a fatal disease caused by the bite of a sandfly; it affects the bone marrow, spleen and liver. At present, the disease is treated through injection-based administration of the drug Amphotericin B but that leads to an uncontrolled release of the drug into a patient’s bloodstream, resulting in high toxicity.

The IIT researchers say their tablets will release Amphotericin B in a sustained and controlled manner over a period of 10 days, which is likely to increase the chances of a patient’s recovery.

The drug uses nanofibres, which are 1,00,000 times thinner than human hair, for the controlled release of drug molecules.

“In order to make controlled-release oral tablets, the drug molecules must be loaded onto a base that dissolves gradually to release the drug over a period of time,” said Dr Chandra Shekhar Sharma, associate professor, creative and advanced research based on nanomaterials (CARBON) laboratory, Department of Chemical Engineering, IIT Hyderabad. Sharma led the research along with professor Saptarshi Majumdar.

“The development of oral, controlled-release tablets for fatal fungal infections and leishmaniasis, will help in better management of the disease burden in the country,” IIT Hyderabad said in a statement Thursday, adding that “the team’s work has been published in the July 2019 issue of the reputed peer-reviewed journal Nano-Structures and Nano-Objects”.

“Many attempts have been made earlier to make oral medication to control the delivery of the drug and bring down costs,” the statement added.

Status of kala-azar in India

In India, malaria, dengue and kala-azar are the top three vector-borne diseases.

According to the latest data by the Ministry of Health and Family Welfare, India registered over 5,700 cases of kala-azar in 2017.

Often referred to as a ‘disease of poverty’, the maximum number of cases were found in the economically underprivileged sections of Jharkhand, Bihar, West Bengal and Uttar Pradesh.

India had missed the 2017 deadline set to eliminate the disease. This was blamed on the absence of concrete or pucca houses in most infected areas and the issue was raised with the rural development ministry.

“As the endemic blocks (states) have a majority of houses made of wood, it is very difficult to eliminate the vector as it (the parasite) dwells in the wooden structure and escapes various measures to kill it,” reported  The Financial Express last year. “Hence, to stop the transmission of infection, pucca houses need to be built.”

source: http://www.theprint.in / The Print / Home> Health / by Himani Chandna / August 22nd, 2019

Amazon opens its largest office building globally in Hyderabad

A view of Amazon’s largest campus building anywhere globally at Gachibowli in Hyderabad, a facility spread over 9.5 acres and comprising three million square feet of built up area.   | Photo Credit:  Nagara Gopal

Its largest campus building anywhere globally which can seat 15,000 people.

E-commerce giant Amazon formally opened on Wednesday its largest campus building anywhere globally in Hyderabad, a facility spread over 9.5 acres and comprising three million square feet of built up area.

The new campus is Amazon’s first owned office building outside the U.S. and is the single largest building globally. The office space of 1.8 million sq ft can seat 15,000 people.

“We have room both for growing [new hires] and consolidating” operations at the campus, Country Head Amit Agarwal said.

Amazon currently has eight office spaces in Hyderabad and “it is natural for us to bring people together in one place. This large building also gives us enough space to grow… we will do that in phases. Already 4,000 employees have moved in [to the new campus] from other locations [in Hyderabad].”

On the work that will be undertaken at the campus, Mr. Agarwal, in a media interaction after the inauguration of the facility, said Amazon has over 60,000 employees in the country “serving our global market places, including India”. A third of the employees are housed in Hyderabad. “This is the largest employee base and technology employee base outside of Seattle,” he said, adding software development engineers, machine learning scientists, product managers, finance and many other involved in various functions will be based out of the campus.

Room to grow

Asked on the economic slowdown and the likely impact on the business plans of Amazon, he said, “We haven’t seen any slowdown yet. One reason is e-commerce is very small portion of retail consumption in India, probably less than 3%. When it is that small, there is so much room to grow.”

Macro conditions are unlikely to seriously impact the e-commerce growth, he said, adding Amazon is committed to long term and “does not get distracted by what’s happening in short cycles. We continue to invest, add more selection, continue to make things more affordable, more faster… growing at a very heavy rate,” he said, without sharing numbers.

About investments made in India, he said: “We publicly announced $5 billion of investment so far and another $500 million in food retail. Outside of that we continue to invest in across our businesses.”

$1 billion exports

The company, Mr. Agarwal said, is registering “tremendous growth not just in our national business but also export business [with] 50,000 sellers now using the services to export to many countries outside where Amazon customers are based. That business has actually crossed $1 billion and we expect it to grow to $5 billion in next three years.”

Amazon vice-president (Global Real Estate and Facilities) John Schoettler said Amazon has roughly 40 million sq ft of office space globally across 300 different locations in over 40 countries. “In Seattle [headquarters] we have approximately 12 million sq ft, half of it owned and the rest leased. Hyderabad is the second location where we have our corporate office outside of the US.”

Telangana Home Minister Mohammed Mahmood and Industries and IT Secretary Jayesh Ranjan participated in the inauguration. Besides offices, Amazon in Telangana has three fulfilment centres offering more than 3.2 million cubic feet of storage space to sellers, two sort centres with 100,000 square feet of processing capacity and 90 delivery stations.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Hyderabad / by N. Ravi Kumar / Hyderabad – August 21st, 2019

Harimohan Paruvu’s biography on Dr MV Sridhar highlights the winning attitude

Harimohan Paruvu   | Photo Credit: WSubrahmanyam

In the biography of ‘Doc’ MV Sridhar, Harimohan Paruvu captures the essence of why the late cricketer was loved and respected by all

Former cricketer Harimohan Paruvu was in a dilemna when Dr M Pushpa came to him with a request to write a biography on her late son, the former Hyderabad cricket captain and cricket administrator, Dr MV Sridhar. Harimmohan was not keen on writing biographies, but when she said, ‘Youngsters could learn from his life and be inspired,’ he saw reason enough to take it up.

The book The Renaissance Man – ‘Doc’ MV Sridhar released recently, narrates the life story of the late cricketer.

Interspersed with photographs and anecdotes, the book focusses on the man and the way he excelled in different roles —as a doctor, a Hyderabad first-class cricketer, corporate executive and cricket administrator.

Being his junior, Harimohan Paruvu had known Sridhar from his school days. “I knew a lot of his schoolmates and teachers too but when I interviewed 64 people for the book, several new facets were revealed to me — his passion, his humility, his focus, concentration, his intelligence. So many people had been so deeply impacted by him,” he shares.

Chronologically divided into different chapters, the book narrates his childhood, schooling at All Saint’s High School, his jazz years, getting high runs for Hyderabad, family bond, corporate stint, cricket administration and BCCI stories. His medical college days not only make for a fascinating chapter but were also arguably the ‘best phase in Sridhar’s life, full of fun and friends’. When Sridhar entered a room, people’s faces would light up; he would make everyone laugh with his jokes.

Being a cricketer had been Sridhar’s dream, but his grandfather was keen that he study medicine; Sridhar accepted the decision without any protest. “Without complaining or cribbing, he studied medicine and the best thing was he focussed only on studies for five years,” says Harimohan. The author recalls how he was surprised to learn of Sridhar’s dancing skills. “He was in the singing team; He was not a trained dancer but had a great sense of rhythm. He would write scripts and stage plays in college and excelled in all of these.

With a foreword written by VVS Laxman, the book documents interesting facets of his life. He was a Hyderabad Ranji cricketer, doctor and turned into a corporate when he joined Satyam and then finally became a cricket administrator. Sridhar’s mother shares how people would enquire about the hospital he was working for.

People recall that Sridhar had always been a team player who kept his problems to himself. At the same time, he wouldn’t talk about any of the problems he faced or worries he had; he would only become thoughtful and take responsibility for it. His way of handling a crisis was just to move ahead, taking along everyone in the team — whether in the corporate company he worked in, or in the cricket team he captained. He had a tremendous ability to understand people, without judgement. He was the glue that held people together”

Most of Sridhar’s friends discuss how he pushed them out of their comfort zone to excel, but was always around when they needed help. In the last chapter ‘A star returns to the Pavilion’, Dr Pushpa pens her shock and pain on her son’s death. “We picked up his best qualities and constructed his life so that others can imbibe them,” explains Harimohan.

source: http://www.thehindu.com / The Hindu / Home> Life & Style> Biography / by Neerja Murthy / August 19th, 2019